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1

Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives

Bin Zhu, Brett A. Marinelli, Darren Abbanat, Barbara D. Foleno, Todd C. Henninger, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 204 KB

english, 2006

2

The enantioselective conversion of ortho-substituted benzoic acids to chiral cyclohexane derivatives

Arthur G. Schultz, Padmanabhan Sundararaman, Mark Macielag, Frank P. Lavieri, Martha Welch

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 197 KB

english, 1985

3

An enantioselective method for reductive alkylation of aromatic carboxylic acid derivatives. Examination of the factors that provide stereoselectivity

Schultz, Arthur G., Macielag, Mark., Sundararaman, Padmanabhan., Taveras, Arthur G., Welch, Martha.

Journal:

Journal of the American Chemical Society

Year:

1988

Language:

english

File:

PDF, 2.47 MB

english, 1988

4

An Improved Non-chromatographic Scale-up Synthesis of a New 1,6,7,8-Substituted-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid as a Potent Bacterial Topoisomerase Inhibitor

Li, Xun, Youells, Scott, Russell, Ronald K., Roessler, Armin, Schmid, Tobias, Faessler, Roger, Weidner-Wells, Michele A., Grant, Eugene B., Macielag, Mark J.

Journal:

Organic Preparations and Procedures International

Year:

2010

Language:

english

File:

PDF, 296 KB

english, 2010

5

The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL)

Zhu, Bin, Connolly, Peter J., Zhang, Sui-Po, Chevalier, Kristen M., Milligan, Cynthia M., Flores, Christopher M., Macielag, Mark J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.67 MB

2020

6

GPR120 agonists for the treatment of diabetes: a patent review (2014-present)

Zhang, Xuqing, Macielag, Mark J.

Journal:

Expert Opinion on Therapeutic Patents

Year:

2020

File:

PDF, 1.91 MB

2020

7

ChemInform Abstract: A Convenient Synthesis of 3,5-Bis(trifluoromethyl)salicylic Acid.

Z. SUI, M. J. MACIELAG

Journal:

Year:

1998

File:

PDF, 31 KB

1998

8

ChemInform Abstract: SAR Studies of Diaryltriazoles Against Bacterial Two-Component Regulatory Systems and Their Antibacterial Activities.

Z. SUI, J. GUAN, D. J. HLASTA, M. J. MACIELAG, B. D. FOLENO, R. M. GOLDSCHMIDT, M. J. LOELOFF, G. C. WEBB, J. F. BARRETT

Journal:

Year:

1998

File:

PDF, 29 KB

1998

9

ChemInform Abstract: Amidino Benzimidazole Inhibitors of Bacterial Two-Component Systems

Michele A. Weidner-Wells, Kwasi A. Ohemeng, Van N. Nguyen, Stephanie Fraga-Spano, Mark J. Macielag, Harvey M. Werblood, Barbara D. Foleno, Glenda C. Webb, John F. Barrett, Dennis J. Hlasta

Journal:

Year:

2001

File:

PDF, 32 KB

2001

10

Synthesis and Antibacterial Activity of Pyrroloaryl-Substituted Oxazolidinones.

Steven D. Paget, Barbara D. Foleno, Christine M. Boggs, Raul M. Goldschmidt, Dennis J. Hlasta, Michele A. Weidner-Wells, Harvey M. Werblood, Ellyn Wira, Karen Bush, Mark J. Macielag

Journal:

Year:

2004

File:

PDF, 156 KB

2004

11

The Synthesis and Antimicrobial Evaluation of a New Series of isoxazolinyl Oxazolidinones.

Michele A. Weidner-Wells, Harvey M. Werblood, Raul Goldschmidt, Karen Bush, Barbara D. Foleno, Jamese J. Hilliard, John Melton, Ellyn Wira, Mark J. Macielag

Journal:

Year:

2004

File:

PDF, 22 KB

2004

12

Synthesis and Antibacterial Activity of C-6 Carbamate Ketolides, a Novel Series of Orally Active Ketolide Antibiotics.

Todd C. Henninger, Xiaodong Xu, Darren Abbanat, Ellen Z. Baum, Barbara D. Foleno, Jamese J. Hilliard, Karen Bush, Dennis J. Hlasta, Mark J. Macielag

Journal:

Year:

2004

Language:

english

File:

PDF, 28 KB

english, 2004

13

15-Amido Erythromycins: Synthesis and in vitro Activity of a New Class of Macrolide Antibiotics.

Simon J. Shaw, Darren Abbanat, Gary W. Ashley, Karen Bush, Barbara Foleno, Mark Macielag, Dan Zhang, David C. Myles

Journal:

Year:

2005

File:

PDF, 15 KB

2005

14

ChemInform Abstract: An Improved Non-chromatographic Scale-up Synthesis of a New 1,6,7,8-Substituted-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid (V) as a Potent Bacterial Topoisomerase Inhibitor.

Xun Li, Scott Youells, Ronald K. Russell, Armin Roessler, Tobias Schmid, Roger Faessler, Michele A. Weidner-Wells, Eugene B. Grant, Mark J. Macielag

Journal:

Year:

2010

File:

PDF, 28 KB

2010

15

Capillary zone electrophoresis studies of motilin peptides: Effects of charge, hydrophobicity, secondary structure and length

James R. Florance, Zenon D. Konteatis, Mark J. Macielag, Ralph A. Lessor, Alphonse Galdes

Journal:

Journal of Chromatography A

Year:

1991

Language:

english

File:

PDF, 485 KB

english, 1991

16

Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones

Steven D. Paget, Barbara D. Foleno, Christine M. Boggs, Raul M. Goldschmidt, Dennis J. Hlasta, Michele A. Weidner-Wells, Harvey M. Werblood, Ellyn Wira, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 175 KB

english, 2003

17

Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl) quinolones

Bin Zhu, Brett A. Marinelli, Raul Goldschmidt, Barbara D. Foleno, Jamese J. Hilliard, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 695 KB

english, 2009

18

The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones

Michele A. Weidner-Wells, Harvey M. Werblood, Raul Goldschmidt, Karen Bush, Barbara D. Foleno, Jamese J. Hilliard, John Melton, Ellyn Wira, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 258 KB

english, 2004

19

Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics

Todd C. Henninger, Xiaodong Xu, Darren Abbanat, Ellen Z. Baum, Barbara D. Foleno, Jamese J. Hilliard, Karen Bush, Dennis J. Hlasta, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 294 KB

english, 2004

20

Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes

Xiaodong Xu, Todd Henninger, Darren Abbanat, Karen Bush, Barbara Foleno, Jamese Hilliard, Mark Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 160 KB

english, 2005

21

Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides

Eugene B. Grant, Deodialsingh Guiadeen, Darren Abbanat, Barbara D. Foleno, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 167 KB

english, 2006

22

Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements

Steven D. Paget, Christine M. Boggs, Barbara D. Foleno, Raul M. Goldschmidt, Dennis J. Hlasta, Michele A. Weidner-Wells, Harvey M. Werblood, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

23

Synthesis and antibacterial activity of C6-carbazate ketolides

Manomi A. Tennakoon, Todd C. Henninger, Darren Abbanat, Barbara D. Foleno, Jamese J. Hilliard, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 178 KB

english, 2006

24

Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives

Bin Zhu, Brett A. Marinelli, Darren Abbanat, Barbara D. Foleno, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

25

Novel erythromycin A derivatives: synthesis of 11,12-benzoxazine ketolides

Bin Zhu, Amy Maden, Mark J. Macielag

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

26

The synthesis of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their ketolides

Eugene B. Grant, Jesse M. Weiss, Shawn Branum, Stuart Hayden, Sigmond Johnson, Deodialsingh Guiadeen, William V. Murray, Mark J. Macielag

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 164 KB

english, 2005

27

The regioselectivity and stereoselectivity of the photorearrangement of 3-methoxy-4- methoxycarbonyl-4-methyl-2,5-cyclohexadien-1-one

Arthur G. Schultz, Frank P. Lavieri, Mark Macielag

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 236 KB

english, 1986

28

Amidino benzimidazole inhibitors of bacterial two-component systems

Michele A. Weidner-Wells, Kwasi A. Ohemeng, Van N. Nguyen, Stephanie Fraga-Spano, Mark J. Macielag, Harvey M. Werblood, Barbara D. Foleno, Glenda C. Webb, John F. Barrett, Dennis J. Hlasta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 142 KB

english, 2001

29

Synthesis and biological activities of novel β-Carbolines as PDE5 inhibitors

Zhihua Sui, Jihua Guan, Mark J. Macielag, Weiqin Jiang, Yuhong Qiu, Patricia Kraft, Sheela Bhattacharjee, T.Matthew John, Elizabeth Craig, Donna Haynes-Johnson, Joanna Clancy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 193 KB

english, 2003

30

SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities

Zhihua Sui, Jihua Guan, Dennis J. Hlasta, Mark J. Macielag, Barbara D. Foleno, Raul M. Goldschmidt, Michael J. Loeloff, Glenda C. Webb, John F. Barrett

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 294 KB

english, 1998

31

Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: Pharmacophore identification based on the screening hit closantel

Dennis J. Hlasta, James P. Demers, Barbara D. Foleno, Stephanie A. Fraga-Spano, Jihua Guan, Jamese J. Hilliard, Mark J. Macielag, Kwasi A. Ohemeng, Cheryl M. Sheppard, Zhihua Sui, Glenda C. Webb, Mich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 276 KB

english, 1998

32

New approaches in the treatment of bacterial infections

Karen Bush, Mark Macielag

Journal:

Current Opinion in Chemical Biology

Year:

2000

Language:

english

File:

PDF, 136 KB

english, 2000

33

15-Amido Erythromycins: Synthesis and in Vitro Activity of a New Class of Macrolide Antibiotics

Shaw, Simon J, Abbanat, Darren, Ashley, Gary W, Bush, Karen, Foleno, Barbara, Macielag, Mark, Zhang, Dan, Myles, David C

Journal:

The Journal of Antibiotics

Year:

2005

File:

PDF, 151 KB

2005

34

Preparation of Erythromycin Analogs Having Functional Groups at C-15

Ashley, Gary W, Burlingame, Mark, Desai, Ruchir, Fu, Hong, Leaf, Tim, Licari, Peter J, Tran, Chau, Abbanat, Darren, Bush, Karen, Macielag, Mark

Journal:

The Journal of Antibiotics

Year:

2006

Language:

english

File:

PDF, 155 KB

english, 2006

35

Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase

Robicsek, Ari, Strahilevitz, Jacob, Jacoby, George A, Macielag, Mark, Abbanat, Darren, Hye Park, Chi, Bush, Karen, Hooper, David C

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 208 KB

english, 2005

36

Meeting Highlights Anti-infectives: 36th Interscience Conference on Antimicrobial Agents and Chemotherapy New Orleans, Louisiana, USA, September 15 – 18, 1996

Barrett, John F, Macielag, Mark J, Fernandez, Jeffrey, Hlasta, Dennis J

Journal:

Expert Opinion on Investigational Drugs

Year:

1996

Language:

english

File:

PDF, 559 KB

english, 1996

37

Characterization of a novel phosphodiesterase type 5 inhibitor: JNJ-10258859

Yuhong Qiu, Sheela Bhattacharjee, Patricia Kraft, T.Mathew John, Elizabeth Craig, Donna Haynes-Johnson, Jihua Guan, Weiqin Jiang, Mark Macielag, Zhihua Sui, Joanna Clancy, Scott Lundeen

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 355 KB

english, 2003

38

Synthesis and characterization of site-specific biotinylated probes for the motilin receptor

MARK J. MACIELAG, THEO PEETERS, INGE DEPOORTERE

Journal:

Chemical Biology & Drug Design

Year:

1994

Language:

english

File:

PDF, 618 KB

english, 1994

39

New β-lactam antibiotics and β-lactamase inhibitors

Bush, Karen, Macielag, Mark J

Journal:

Expert Opinion on Therapeutic Patents

Year:

2010

Language:

english

File:

PDF, 720 KB

english, 2010

40

The Motilin Antagonist ANQ-11125 Blocks Motilide-Induced Contractions in Vitro in the Rabbit

T.L. Peeters, I. Depoortere, M.J. Macielag, R. Dharanipragada, M.S. Marvin, J.R. Florance, A. Galdes

Journal:

Biochemical and Biophysical Research Communications

Year:

1994

File:

PDF, 312 KB

1994

41

Antagonistic properties of [Phe3,Leu13]porcine motilin

Inge Depoortere, Marc J. Macielag, Alphonse Galdes, Theo L. Peeters

Journal:

European Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 606 KB

english, 1995

42

Taking inventory: antibacterial agents currently at or beyond Phase 1

Karen Bush, Mark Macielag, Michele Weidner-Wells

Journal:

Current Opinion in Microbiology

Year:

2004

Language:

english

File:

PDF, 301 KB

english, 2004

43

A role for schwann cells in the neuroregenerative effects of a non-immunosuppressive fk506 derivative, jnj460

R.B Birge, S Wadsworth, R Akakura, H Abeysinghe, R Kanojia, M MacIelag, J Desbarats, M Escalante, K Singh, S Sundarababu, K Parris, G Childs, A August, J Siekierka, D.E Weinstein

Journal:

Year:

2004

Language:

english

File:

PDF, 1.63 MB

english, 2004

44

Intramolecular cycloadditions to oxyallyl zwitterions generated from photorearrangements of 2,5-cyclohexadien-1-ones

Schultz, Arthur G., Macielag, Mark, Plummer, Mark

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 743 KB

english, 1988

45

Biotinylated [Leu13]-porcine motilin for use as a receptor probe

M.J. Macielag, I. Depoortere, T.L. Peeters

Journal:

Regulatory Peptides

Year:

1992

Language:

english

File:

PDF, 71 KB

english, 1992

46

D-amino acid and alanine scan of porcine motilin

TL Peeters, MJ Macielag, I Depoortere, Z Konteatis, G Vantrappen, R Lessor, J Florance, A Galdes

Journal:

Regulatory Peptides

Year:

1992

Language:

english

File:

PDF, 88 KB

english, 1992

47

The motilin analog, OHM-11638, induces phase III-like contractions of the upper gut and enhances gastric emptying in the conscious dog

M.J. Macielag, R.L. Gregory, I. Depoortere, J. Florance, T.L. Peelers, J. Ward, J. Kim-Detteback, A Galdes

Journal:

Gastroenterology

Year:

1995

Language:

english

File:

PDF, 156 KB

english, 1995

48

d-Amino acid and alanine scans of the bioactive portion of porcine motilin

Theo L. Peeters, Mark J. Macielag, Inge Depoortere, Zenon D. Konteatis, James R. Florance, Ralph A. Lessor, Alphonse Galdes

Journal:

Year:

1992

Language:

english

File:

PDF, 520 KB

english, 1992

49

Synthesis and in vitro evaluation of [Leu13]porcine motilin fragments

Mark J. Macielag, Theo L. Peeters, Zenon D. Konteatis, James R. Florance, Inge Depoortere, Ralph A. Lessor, Lance A. Bare, Yea-Shun Cheng, Alphonse Galdes

Journal:

Year:

1992

Language:

english

File:

PDF, 471 KB

english, 1992

50

Birch reduction and reductive alkylation of benzonitriles and benzamides

Schultz, Arthur G., Macielag, Mark

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 728 KB

english, 1986